Ampoule Filling And Sealing Machine Manufacturer & Supplier In Great Britain
Ampoule Filling And Sealing Machine Details
In pharmaceutical injectable manufacturing, ampoule filling and sealing is a critical process that directly affects product sterility, dosage accuracy, and patient safety. Even minor inconsistencies during filling or flame sealing can compromise the integrity of injectable products. For this reason, pharmaceutical manufacturers require machines that deliver precise filling, controlled sealing, and reliable repeatability under CGMP conditions.
The Ampoule Filling and Sealing Machine manufactured by Technogen Enterprise is designed to meet these stringent requirements. Widely used by pharmaceutical plants across Great Britain, including facilities in London’s pharmaceutical clusters, Cambridge science parks, the Midlands manufacturing belt, Manchester, and Northern England, this machine offers dependable performance for small to medium-scale ampoule production lines.
What Is an Ampoule Filling and Sealing Machine?
An Ampoule Filling and Sealing Machine is a specialised pharmaceutical packaging machine used to fill liquid formulations into glass ampoules and seal them hermetically by flame sealing. The process ensures accurate dosing, prevents contamination, and protects sensitive formulations from external exposure.
This machine integrates multiple functions into a single, synchronized operation:
Controlled ampoule feeding
Accurate liquid filling
Pre-gassing and post-gassing (optional)
Flame sealing of ampoule necks
Collection of sealed ampoules in trays
Available in 4-head, 6-head, and 8-head configurations, the machine allows manufacturers to select a model based on their required production output.
Machine Overview
The Ampoule Filling and Sealing Machine from Technogen Enterprise is engineered with a focus on synchronization, hygiene, and operator safety. The machine frame is fabricated from AISI 304 stainless steel, while all liquid contact parts are made from AISI 316L stainless steel, ensuring compatibility with pharmaceutical formulations and compliance with CGMP standards.
Key operational highlights include:
No Ampoule – No Filling system to prevent wastage
Optional pre and post gassing systems for sensitive formulations
Diving nozzles to minimise foaming and spillage
Draw jaw–based sealing unit with a pusher mechanism
Infeed and outfeed tray-based ampoule handling
Production counting arrangement for batch monitoring
This configuration ensures stable, repeatable performance in injectable manufacturing environments.
Working Principle of the Ampoule Filling and Sealing Machine
1. Ampoule Loading
Empty ampoules are manually loaded into the infeed tray. From here, they are transferred into the filling and sealing zone through a controlled transportation mechanism.
2. Ampoule Positioning
Ampoules are precisely positioned beneath the filling nozzles. The machine ensures correct alignment to prevent breakage or misfilling.
3. No Ampoule – No Filling
If an ampoule is missing at any filling station, the filling cycle is automatically skipped, avoiding liquid wastage and contamination.
4. Liquid Filling
Liquid is dispensed into the ampoule through diving nozzles, which enter the ampoule neck during filling. This design reduces foaming and prevents spillage.
5. Pre-Gassing (Optional)
For oxygen-sensitive formulations, a pre-gassing system can be incorporated to flush inert gas before sealing.
6. Flame Sealing
The filled ampoule moves to the sealing station, where the neck is sealed using a draw jaw sealer. This ensures uniform neck formation and hermetic sealing.
7. Post-Gassing (Optional)
Post-gassing can be applied to further protect the product, depending on formulation requirements.
8. Ampoule Collection
Sealed ampoules are pushed into the outfeed tray using a pusher mechanism, ensuring gentle handling and orderly collection.
Salient Features
CGMP-compliant machine design
Special induction gear motor and worm gearbox for superior synchronisation
Machine frame fabricated from AISI 304 stainless steel
All liquid contact parts made from AISI 316L stainless steel
Diving nozzles to avoid foaming and spillage
Filling capacity up to 20 ml with minimal change parts
Provision for pre and post gassing systems
Integrated infeed and outfeed tray-based loading and collection
Production counting arrangement for batch control
Emergency stop button for operator safety
Technical Specifications
| Parameter | TGAFS-60 | TGAFS-120 | TGAFS-180 |
|---|---|---|---|
| Machine Type | 4 Head | 6 Head | 8 Head |
| Output | 60 ampoules/min | 120 ampoules/min | 160 ampoules/min |
| Filling Accuracy | ±1% | ±1% | ±1% |
| Filling Range | 1 ml to 10 ml | 1 ml to 10 ml | 1 ml to 10 ml |
| Number of Filling Heads | 4 | 6 | 8 |
| Power Requirement | 230 V, Single Phase, 50 Hz | ||
| Electrical Supply | 1 HP | 1.5 HP | 2 HP |
| Ampoule Size | 1 ml to 10 ml | ||
| Net Weight | 350 kg | 450 kg | 500 kg |
| Machine Dimensions (L×W×H) mm | 1250×1180×1250 | 1590×1180×1250 | 1850×1200×1300 |
Add-On Features
PLC and HMI interface
Toughened glass or acrylic safety cabinet
Applications & Industry Use
The Ampoule Filling and Sealing Machine is primarily used in:
Pharmaceutical injectable manufacturing
Sterile liquid formulations
Hospital and clinical supply units
Contract manufacturing organisations (CMOs)
Pharmaceutical plants across Southern England, the Midlands, and Northern England rely on ampoule filling and sealing systems to maintain sterility, compliance, and batch consistency.
Advantages & Buyer Benefits
Accurate Dosage Control
Consistent ±1% filling accuracy ensures patient safety and regulatory compliance.
Reduced Product Loss
“No Ampoule – No Filling” logic prevents unnecessary wastage.
Hygienic Construction
AISI 316L contact parts meet injectable manufacturing standards.
Flexible Production
Multiple head configurations allow output scaling.
Product Protection
Optional pre and post gassing safeguard oxygen-sensitive formulations.
Safe Operation
Emergency stop and safety cabinet options protect operators.
Reliable Sealing
Draw jaw sealing delivers uniform ampoule neck formation.
Why Choose Technogen Enterprise
Technogen Enterprise is a trusted manufacturer, supplier, and exporter of pharmaceutical packaging machinery, serving regulated markets worldwide. Manufacturers across Great Britain’s pharmaceutical sector choose Technogen Enterprise for:
Proven expertise in ampoule filling and sealing technology
Robust stainless-steel fabrication
CGMP-focused machine design
Flexible configurations based on production needs
Reliable documentation, support, and service
Frequently Asked Questions (FAQs)
1. What ampoule sizes can the machine handle?
It supports ampoules from 1 ml to 10 ml.
2. Is pre-gassing mandatory?
No, pre and post gassing systems are optional based on product needs.
3. How is filling accuracy maintained?
Through precise metering and synchronized filling mechanisms.
4. Can output be increased later?
Yes, by selecting higher head configurations.
5. Is the machine suitable for pharmaceutical injectables?
Yes, it is designed specifically for pharmaceutical applications.
6. How are sealed ampoules collected?
Via an integrated pusher mechanism into outfeed trays.